The Protein Design Lab

Explore the cutting edge of computational protein design — from inverse folding with ProteinMPNN to fine-tuning binding models and reinforcement learning for sequence optimization.

What You'll Learn

• How ProteinMPNN works and how to use it for inverse folding
• Fine-tuning models on binding data with BindingGYM
• Reinforcement learning approaches for protein sequence design
• The landscape of modern protein design tools

Why This Wall Matters

Protein design is one of the most exciting frontiers in computational biology. Tools like ProteinMPNN and RFdiffusion are enabling researchers to design proteins that never existed in nature. This wall takes you from understanding these tools to actually using them.

Warning: this wall is steep. The routes here assume you're comfortable with ML fundamentals from earlier walls.